Harry Connick Jr.
Dr. Dennis Slamon
Tammy Blanchard
Nicole Wilson
Amanda Bynes
Jamie McGrath
Jennifer Coolidge
Tish
Angie Harmon
Lilly Tartikoff
John Benjamin Hickey
Blake Rogers
Regina King
Ellie Jackson
Swoosie Kurtz
Elizabeth
Paula Cale
Donna Slamon (as Paula Cale Lisbe)
Amy Madigan
Fran Visco
Bernadette Peters
Barbara Bradfield
Trudie Styler
Tina
Melissa McBride
Sally
J. Patrick McNamara
Dr. Rice
Jackson Hurst
Josh
Brandon Smith
Pharmacy Board Member
Bruce McKinnon
Dean Bradfield
Tom Nowicki
Carl Reinhardt
William Ragsdale
Andy Marks
Naima Lett
Nurse Carol (as Naima Imani Lett)
Griff Furst
Charlie Wilson
Maria Howell
Kate
Joe Nemmers
Ron Perelman
Rhoda Griffis
Bindy Blake
Lance E. Nichols
Dr. Brown
Louis Herthum
Dr. Banks
Kim Wall
Marci
Connor Hill
Sam Wilson Age 5
Tyler Case
Sam Wilson Age 7 and 8
Cooper Cason
Sam Wilson Age 14
Sophia Watson
Joey Lyn Slamon Age 7
Abby Rao
Joey Lyn Slamon Age 9
Sam Richardson
Matt Slamon Age 3 - 5
Ben Lux
Matt Slamon Age 7 (as Benjamin Lux)
Austin Lux
Matt Slamon Age 9
Elliott Grey
Board Member
Andrew Matthews
Darrin Bradfield
Evan Gamble
Peter Wilson
Shanna Forrestall
Runner
Crew
Dan Ireland
Director
Craig Zadan
Producer
Neil Meron
Producer
Robert Bazell
Book
Vivienne Radkoff
Executive Producer
Vivienne Radkoff
Teleplay
Renée Zellweger
Executive Producer
Margaret Goodspeed
Editor
James Chressanthis
Director of Photography
Susan Edelman
Casting
Christopher Nash
Dolly Grip
Halli Cauthery
Original Music Composer